Risk factors of polycystic ovarian syndrome among Li People

OBJECTIVE@#To study the relevant risk factors of polycystic ovarian syndrome (PCOS) of Li People so as to provide basis for early diagnosis and treatment of PCOS.@*METHODS@#With case-control study method, 285 cases of PCOS of Li People were as recruited case group, and 580 cases of non-PCOS of female Li People as control group. Questionnaire was adopted to collect data regarding risk factors of PCOS, then the risk factors of PCOS was searched by univariate and multivariate analysis.@*RESULTS@#Multivariate analysis showed that the risk factors of PCOS included in menstrual cycle disorder (OR = 5.824), bad mood (OR = 2.852), family history of diabetes (OR = 7.008), family history of infertility (OR = 11.953), menstrual irregularity of mother (OR = 2.557) and lack of physical exercise (OR = 1.866).@*CONCLUSIONS@#To target the high risk factors of menstrual cycle disorder, family history of diabetes, family history of infertility, family history of diabetes, bad mood and lack of physical exercise of female population, we should implement early screen, diagnose and treatment of POCS in order to reduce the incidence rate of PCOS and improve prognosis of PCOS.

Risk factors of polycystic ovarian syndrome among Li People

Objective: To study the relevant risk factors of polycystic ovarian syndrome (PCOS) of Li People so as to provide basis for early diagnosis and treatment of PCOS. Methods: With case-control study method, 285 cases of PCOS of Li People were as recruited case group, and 580 cases of non-PCOS of female Li People as control group. Questionnaire was adopted to collect data regarding risk factors of PCOS, then the risk factors of PCOS was searched by univariate and multivariate analysis. Results: Multivariate analysis showed that the risk factors of PCOS included in menstrual cycle disorder (OR = 5.824), bad mood (OR = 2.852), family history of diabetes (OR = 7.008), family history of infertility (OR = 11.953), menstrual irregularity of mother (OR = 2.557) and lack of physical exercise (OR = 1.866). Conclusions: To target the high risk factors of menstrual cycle disorder, family history of diabetes, family history of infertility, family history of diabetes, bad mood and lack of physical exercise of female population, we should implement early screen, diagnose and treatment of POCS in order to reduce the incidence rate of PCOS and improve prognosis of PCOS.

2-Bromoethylamine protects vascular endothelium by inhibiting SSAO activity in diabetic rats / 生理学报

The purpose of this study was to investigate the change of aortic semicarbazide-sensitive amine oxidase (SSAO) activity in diabetic rats and examine the effect of 2-bromoethylamine (2-BEA) on SSAO activity and vascular endothelium in diabetic rats. SSAO was prepared from rat aorta. For assessment of the inhibitory effect, the enzymes were preincubated in the presence of different concentrations of 2-BEA before the addition of benzylamine in vitro. Type 1 diabetic rat model was induced by a single intraperitoneal injection of streptozotocin (STZ). Sprague Dawley (SD) rats were randomly divided into normal control group (NC), diabetic model group (DM), 2-BEA 5 mg/kg group, 2-BEA 20 mg/kg group (n = 10 in each group). 2-BEA was administered daily via intraperitoneal injection for 8 weeks. At the end of 8 weeks, blood sample was collected from the abdominal aorta. Plasma nitric oxide (NO) was determined by nitrate reductase method. Plasma endothelin-1 (ET-1) was determined by radioimmunoassay. Aorta SSAO was determined by high performance liquid chromatography. The aorta was prepared to observe morphological changes and ultramicroscopic structures. The results were as follows: Compared with NC group, aortic SSAO activity and the plasma ET-1 were significantly increased (P < 0.01), and plasma NO was significantly decreased (P < 0.01) in DM group. 2-BEA decreased plasma ET-1 and elevated plasma NO by inhibiting aortic SSAO activity in diabetic rats (P < 0.01), and 2-BEA 20 mg/kg group was more significant than 2-BEA 5 mg/kg group (P < 0.05). Endothelial injury of 2-BEA group rats was less serious than DM group. These results suggest that 2-BEA protect aortic endothelium by inhibiting aortic SSAO activity.

Clinical value of multi-tumor markers protein biochip in the diagnosis of pulmonary carcinoma / 南方医科大学学报

<p><b>OBJECTIVE</b>To assess the value of multi-tumor markers protein biochip in the diagnosis and therapy of pulmonary carcinoma.</p><p><b>METHODS</b>Twelve tumor markers (CA199, NSE, CEA, CA242, Ferrtin, β-HCG, AFP, f-PSA, PSA, CA125, HGH, and CA153) were detected using protein chip in 308 patients with pulmonary carcinoma, 218 with benign lung lesions and 250 healthy subjects.</p><p><b>RESULTS</b>The positivity rate was 72.4% in pulmonary carcinoma cases, obviously higher than that in the benign cases (22.0%, P<0.01) and healthy subjects (5.6%, P<0.01). The positivity rates differed significantly between the pulmonary carcinoma cases of different pathological types. The positivity rates of CEA, CA125, and CA153 were significantly higher in adenocarcinoma cases than in squamous carcinoma cases (P<0.05), and also higher in cases with lymph node metastasis than in those without (71.9% vs 52.1%, P<0.05).</p><p><b>CONCLUSION</b>Protein biochip containing multiple tumor markers provides valuable assistance in the diagnosis and therapeutic effect monitoring of pulmonary carcinoma.</p>

Clinical and pathological analysis of 217 patients with IgA nephropathy from Hainan Province / 南方医科大学学报

<p><b>OBJECTIVE</b>To study the clinical manifestation, pathological features and their correlation in patients with IgA nephropathy from Hainan Province.</p><p><b>METHODS</b>The clinical and pathological data of 217 patients with IgA nephropathy diagnosed by renal biopsy were retrospectively analyzed.</p><p><b>RESULTS</b>The incidence of IgA nephropathy was the highest in patients at the age of 30-39 years (50.38%). Clinically, IgA nephropathy of hematuria + albuminuria type was the most common among the patients (56.68%, 123/217) and associated with severe pathological changes, with 38.21% of the cases having pathological changes above grade III. The pathological types of IgA nephropathy included almost all the pathological types of primary glomerular disease, and type I was the most common (31.34%, 68/217) followed by type II. The progression of the pathological changes was associated with increased rate of hypertension. Immunopathological classification identified 48 (22.12%) simple IgA cases and 106 cases with complement deposition (48.85%).</p><p><b>CONCLUSION</b>IgA nephropathy has diverse clinical manifestations, and the presence of concurrent hypertension often indicates severe pathological changes of the kidneys. For asymptomatic patients with hematuria in the presence or absence of albuminuria, early renal biopsy should be performed and appropriate therapy administered according to the pathological types.</p>